Moléculas quimiotrópicas como mecanismo de orientación del crecimiento axonal y de la migración neuronal durante el desarrollo del sistema nervioso de los mamíferos

Resumen

The chemiotropic hypothesis of Cajal, according to which, during development, connections between neurons are established because of the gradients of diffusible substances present in the environment, which guide the growth cones of the axons, has recently been confirmed by many experiments. The long range activity of these secreted molecules is which have been secreted is therefore accepted as one of the main mechanisms which contribute to the formation of the complex nerve circuitry. Its importance in neuroembriological disorders starts to be recognized.